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Dmitry Korkin - Computational Biology of Coronavirus

Wed, Apr 22, 2020 ·
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Dmitry Korkin is a professor of bioinformatics and computational biology at Worcester Polytechnic Institute, where he specializes in bioinformatics of complex disease, computational genomics, systems biology, and biomedical data analytics. I came across Dmitry's work when in February his group used the viral genome of the COVID-19 to reconstruct the 3D structure of its major viral proteins and their interactions with human proteins, in effect creating a structural genomics map of the coronavirus and making this data open and available to researchers everywhere. We talked about the biology of COVID-19, SARS, and viruses in general, and how computational methods can help us understand their structure and function in order to develop antiviral drugs and vaccines.

Timestamps

  • 2:33 - Viruses are terrifying and fascinating
  • 6:02 - How hard is it to engineer a virus?
  • 10:48 - What makes a virus contagious?
  • 29:52 - Figuring out the function of a protein
  • 53:27 - Functional regions of viral proteins
  • 1:19:09 - Biology of a coronavirus treatment
  • 1:34:46 - Is a virus alive?
  • 1:37:05 - Epidemiological modeling
  • 1:55:27 - Russia
  • 2:02:31 - Science bobbleheads
  • 2:06:31 - Meaning of life

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